Laboratory of Natural Product Chemistry
NATURAL PRODUCT TOTAL SYNTHESIS
Natural product total synthesis provides a platform to access complex and privileged architectures with unique target-specific activities. Our research allows us to study biosynthetic pathways, modulate biological function, and explore chemical diversity for the purposes of efficient access to complex scaffolds and medicinally relevant analogs.
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BIOMIMETIC
We use biomimetic total synthesis to test biosynthetic hypotheses as well as develop new approaches to accessing biosynthetically intractable functional groups. |
CHEMOENZYMATICCombining total synthesis and enzyme chemistry is a powerful method for efficient synthesis. We develop catalysts from polyketide biosynthesis as reagents for chemoenzymatic total syntheses of polyketide natural products. |
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