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PUBLICATIONS

2022

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Synthesis of a Constitutional Isomer of Armeniaspirol A, Pseudoarmeniaspirol A, via Lewis Acid-Mediated Rearrangement 

Michael G. Darnowski, Taylor D. Lanoski, André R. Paquette, and Christopher N. Boddy
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Untargeted metabolomics screening reveals unique secondary metabolite production from Alternaria section Alternaria.

Thomas E. Witte, Nicolas Villeneuve, Samuel W. Shields, Amanda Sproule, Quinn Eggertson, Natalie E. Kim, Christopher N. Boddy, Jeremy R. Dettman and David P. Overy

Frontiers, 2022
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Total and Chemoenzymatic Synthesis of Seongsanamide E

Jordan T. Brazeau-Henrie, André R. Paquette, Allison Q. O’Rourke, Michael G. Darnowski, and Christopher N. Boddy

Org. Lett. 2022
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A comparison of hard and soft direct methods for DNA extraction from soil

Patrick Hill, Mathieu F Dextraze, David Kroetsch, Christopher N. Boddy

​bioRxiv Preprint
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​Biomineralization in Cave Bacteria—Popcorn and Soda Straw Crystal Formations, Morphologies, and Potential Metabolic Pathways


Keegan Koning, Richenda McFarlane, Jessica T. Gosse, Sara Lawrence, Lynnea Carr1, Derrick Horne, Nancy Van Wagoner, Christopher N. Boddy and Naowarat Cheeptham

Frontiers 2022
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RpoN-Based stapled peptides with improved DNA binding suppress Pseudomonas aeruginosa virulence.

André R. Paquette, Sterling R. Payne, Geoffrey A. McKay, Jordan T. Brazeau-Henrie, Micheal G. Darnowski, Anitha Kammili, Federico Bernal, Thien-Fah Mah, Samantha Gruenheid, Dao Nguyencf and Christopher N. Boddy

​RSC Med. Chem. 2022
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Armeniaspirol analogues with more potent Grampositive antibiotic activity show enhanced inhibition of the ATP-dependent proteases ClpXP and ClpYQ.

Michael G. Darnowski, Taylor D. Lanosky, Puneet Labana, Jordan T. Brazeau-Henrie, Nicholas D. Calvert, Mark H. Dornan, Claudia Natola, André R. Paquette, Adam J. Shuhendler and Christopher N. Boddy

RSC Med. Chem. 2022


2021

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Evolution of the Ergot Alkaloid Biosynthetic Gene Cluster Results in Divergent Mycotoxin Profiles in Claviceps purpurea Sclerotia.
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Carmen Hicks, Thomas E. Witte, Amanda Sproule, Tiah Lee, Parivash Shoukouhi, Zlatko Popovic, Jim G. Menzies, Christopher N. Boddy, Miao Liu, David P. Overy


Toxins. 2021 


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​A metabolomic study of vegetative incompatibility in Cryphonectria parasitica.
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Thomas E. Witte, Sam Shields, Graham W. Heberlig, Mike G. Darnowski, 
Anatoly Belov, Amanda Sproule, Christopher N. Boddy, David P. Overy, and Myron L. Smith


Fungal Genet. Biol. 2021 
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Apicidin biosynthesis is linked to accessory chromosomes in Fusarium poae isolates.
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Thomas E. Witte, Linda J. Harris, Hai D. T. Nguyen, Anne Hermans, Anne Johnston, Amanda Sproule, Jeremy R Dettman, Christopher N Boddy, David P. Overy

BMC Genomics, 2021
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Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria. 

Puneet Labana, Mark H. Dornan, Matthew Lafrenière, Tomasz L. Czarny, Eric D. Brown, John P. Pezacki, Christopher N. Boddy 

Cell Chem. Biol. 2021 

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Accessory Chromosome-Acquired Secondary Metabolism in Plant Pathogenic Fungi: The Evolution of Biotrophs Into Host-Specific Pathogens

Thomas E. Witte, Nicolas Villeneuve, Christopher N. Boddy, David P. Overy

Front. Microbiol. 2021 

2020

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Thioesterase from Cereulide Biosynthesis Is Responsible for Oligomerization and Macrocyclization of a Linear Tetradepsipeptide.

Graham W. Heberlig, Christopher N. Boddy

J. Nat. Prod. 2020

2019

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Whole Genome Sequencing and Metabolomic Study of Cave Streptomyces Isolates ICC1 and ICC4.

​Jessica Thandara Gosse, Soumya Ghosh, Amanda Sproule, David Overy, Naowarat Cheeptham, Christopher N. Boddy

Front. Microbio. ​2019
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Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.

Nicolas Huguenin-Dezot, Diego A. Alonzo, Graham W. Heberlig, Mohan Mahesh, Duy P. Nguyen, Mark H. Dornan, Christopher N. Boddy, T. Martin Schmeing, Jason W. Chin

Nature 2019

2018

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Draft Genome Sequence of the Type Strain Streptomyces armeniacus ATCC 15676.

Puneet Labana, Jessica T. Gosse, Christopher N. Boddy

Microbiol. Resour. Announc. 2018
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Inhibition of Bacterial Gene Transcription with an RpoN-Based Stapled Peptide.

​Sterling R Payne, Daniel I. Pau, Amanda L. Whiting, Ye Joon Kim, Blaze M. Pharoah, Christina Moi, Christopher N. Boddy, Federico Bernal

Cell Chem. Biol. 2018
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​Chemoenzymatic macrocycle synthesis using resorcylic acid lactone thioesterase domains.

Graham W Heberlig, Jesse T. C. Brown, Ryan D Simard, Monica Wirz, Wei Zhang, Meng Wang, Leah I. Susser, Mark E. Horsman, Christopher N. Boddy

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Org. Biomol. Chem. 2018

2017

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Inducible T7 RNA Polymerase-mediated Multigene Expression System, pMGX.

Mohamed I. Hassan, Fern R. McSorley, Kinya Hotta, Christopher N. Boddy

J. Vis. Exp. 2017
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Sampling Terrestrial Environments for Bacterial Polyketides.

Patrick Hill, Graham W. Heberlig, Christopher N Boddy

Molecules 2017

2016

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Natural products: Mapping an amazing thicket.

Mark E. Horsman, Christopher N. Boddy

Nat. Chem. Biol. 2016

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Portable, On-Demand Biomolecular Manufacturing.

Keith Pardee, Shimyn Slomovic, Peter Q. Nguyen, Jeong Wook Lee, Nina Donghia, Devin Burrill, Tom Ferrante, Fern R. McSorley, Yoshikazu Furuta, Andyna Vernet, Michael Lewandowski, Christopher N. Boddy, Neel S. Joshi, James J. Collins

Cell 2016 

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Total Biosynthesis of Legionaminic Acid, a Bacterial Sialic Acid Analogue.

​Mohamed I. Hassan, Benjamin R Lundgren, Michael Chaumun, Dennis M. Whitfield, Brady Clark, Ian C. Schoenhofen, Christopher N. Boddy

Angew. Chem. Int. Ed. Engl. 2016
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First-in-class small molecule potentiators of cancer virotherapy.

Mark H Dornan, Ramya Krishnan, Andrew M. Macklin, Mohammed Selman, Nader El Sayes, Hwan Hee Son, Colin Davis, Andrew Chen, Kerkeslin Keillor, Penny J Le, Christina Moi, Paula Ou, Christophe Pardin, Carlos R. Canez, Fabrice Le Boeuf, John C Bell, Jeffrey C. Smith, Jean-Simon Diallo, Christopher N. Boddy

Nat. 
Sci. Rep. 2016


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Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis

Panos Argyropoulos, Fabien Bergeret, Christophe Pardin, Janice M Reimer, Atahualpa Pinto, Christopher N Boddy, T Martin Schmeing

Biochim. Biophys. Acta. 2016 
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Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?

Mark E Horsman 1, Taylor P A Hari 1, Christopher N Boddy 1

Nat Prod Rep. 2016
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Diastereoseletive Transannular Oxa-Conjugate Addition Generates the 2,6-cis-Disubstituted Tetrahydropyran of Neopeltolide.

Taylor P A Hari 1, Burkardt I Wilke 2, James A Davey 1, Christopher N Boddy 1

J. Org. Chem. 2016
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The Use of ClusterMine360 for the Analysis of Polyketide and Nonribosomal Peptide Biosynthetic Pathways.

Nicolas Tremblay, Patrick Hill, Kyle R. Conway, Christopher N. Boddy

Methods Mol. Biol. 2016


2015

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Draft Genome Sequence of Streptomyces sp. Strain PBH53, Isolated from an Urban Environment

Jessica T Gosse, Patrick Hill, Scot E. Dowd, Christopher N. Boddy

Genome Announc. 2015
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Thermoplasmonic ssDNA Dynamic Release from Gold Nanoparticles Examined with Advanced Fluorescence Microscopy

Sabrina Simoncelli, Hasitha de Alwis Weerasekera, Chiara Fasciani, Christopher N. Boddy, Pedro F Aramendia,  Emilio I Alarcon, Juan C Scaiano

J. Phys. Chem. Lett. 2015

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Modulation of antifreeze activity and the effect upon post-thaw HepG2 cell viability after cryopreservation

Chantelle J. Capicciotti, Jessica S. Poisson, Christopher N. Boddy, Robert N. Ben


Cryobiology 2015 

Pre-2015 Publications​
BODDY LAB
Center for Chemical and Synthetic Biology
​Center for Catalysis Research and Innovation
Department of Chemistry and Biomolecular Sciences 
Unversity of Ottawa, Ottawa, ON Canada K1N 6N5
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  • Research
  • Publications
  • Chris
  • Team
  • Resources