PUBLICATIONS
2024
Comprehensive untargeted lipidomic profiling of third generation lentiviral vectors and packaging cells
Joshua A. Roberts, Elena Godbout, Jocelyn A. Menard, Christopher N. Boddy, c Jean-Simon Diallobd and Jeffrey C. Smith Mol. Omics, 2024 |
Thioesterases as tools for chemoenzymatic synthesis of macrolactones André R. Paquette, Jordan T. Brazeau-Henrie and Christopher N. Boddy* Chem. Commun. 2024 |
2023
Total and chemoenzymatic synthesis of the lipodepsipeptide rhizomide A
Corinne A. Lepetit, André R. Paquette , Jordan T. Brazeau-Henrie, Christopher N. Boddy a Bioorg. Med. Chem. Lett 2023 |
Double stranded DNA binding stapled peptides, an emerging tool for transcriptional regulation
André R. Paquette, Christopher N. Boddy ChemBioChem 2023 |
Macrocyclization strategies for the total synthesis of cyclic depsipeptides Andre Paquette and Christopher N. Boddy Org. Biomol. Chem. 2023 |
CRISPR-Cas9 Gene Editing and Secondary Metabolite Screening Confirm Fusarium graminearum C16 Biosynthetic Gene Cluster Products as Decalin-Containing Diterpenoid Pyrones
Carmen Hicks, Thomas E. Witte, Amanda Sproule, Anne Hermans, Samuel W. Shields, Ronan Colquhoun, Chris Blackman, Christopher N. Boddy, Rajagopal Subramaniam and David P. Overy J. Fungi 2023 |
Characterization of Arthropeptide B, an Antifungal Cyclic Tetrapeptide from Arthrobacter humicola
Juan Sebastian Gomez, Michael Shaikhet, A. Kiripuvaney Loganathan, Michael G. Darnowski, Christopher N. Boddy, David R. McMullin and Tyler J. Avis J. Chem Ecology 2023 |
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2022
Synthesis of a Constitutional Isomer of Armeniaspirol A, Pseudoarmeniaspirol A, via Lewis Acid-Mediated Rearrangement
Michael G. Darnowski, Taylor D. Lanoski, André R. Paquette, and Christopher N. Boddy JOC, 2022 |
Untargeted metabolomics screening reveals unique secondary metabolite production from Alternaria section Alternaria.
Thomas E. Witte, Nicolas Villeneuve, Samuel W. Shields, Amanda Sproule, Quinn Eggertson, Natalie E. Kim, Christopher N. Boddy, Jeremy R. Dettman and David P. Overy Frontiers, 2022 |
Total and Chemoenzymatic Synthesis of Seongsanamide E
Jordan T. Brazeau-Henrie, André R. Paquette, Allison Q. O’Rourke, Michael G. Darnowski, and Christopher N. Boddy Org. Lett. 2022 |
A comparison of hard and soft direct methods for DNA extraction from soil
Patrick Hill, Mathieu F Dextraze, David Kroetsch, Christopher N. Boddy bioRxiv Preprint |
Biomineralization in Cave Bacteria—Popcorn and Soda Straw Crystal Formations, Morphologies, and Potential Metabolic Pathways Keegan Koning, Richenda McFarlane, Jessica T. Gosse, Sara Lawrence, Lynnea Carr1, Derrick Horne, Nancy Van Wagoner, Christopher N. Boddy and Naowarat Cheeptham Frontiers 2022 |
RpoN-Based stapled peptides with improved DNA binding suppress Pseudomonas aeruginosa virulence.
André R. Paquette, Sterling R. Payne, Geoffrey A. McKay, Jordan T. Brazeau-Henrie, Micheal G. Darnowski, Anitha Kammili, Federico Bernal, Thien-Fah Mah, Samantha Gruenheid, Dao Nguyencf and Christopher N. Boddy RSC Med. Chem. 2022 |
Armeniaspirol analogues with more potent Grampositive antibiotic activity show enhanced inhibition of the ATP-dependent proteases ClpXP and ClpYQ.
Michael G. Darnowski, Taylor D. Lanosky, Puneet Labana, Jordan T. Brazeau-Henrie, Nicholas D. Calvert, Mark H. Dornan, Claudia Natola, André R. Paquette, Adam J. Shuhendler and Christopher N. Boddy RSC Med. Chem. 2022 |
2021
Evolution of the Ergot Alkaloid Biosynthetic Gene Cluster Results in Divergent Mycotoxin Profiles in Claviceps purpurea Sclerotia.
Carmen Hicks, Thomas E. Witte, Amanda Sproule, Tiah Lee, Parivash Shoukouhi, Zlatko Popovic, Jim G. Menzies, Christopher N. Boddy, Miao Liu, David P. Overy Toxins. 2021 |
A metabolomic study of vegetative incompatibility in Cryphonectria parasitica.
Thomas E. Witte, Sam Shields, Graham W. Heberlig, Mike G. Darnowski, Anatoly Belov, Amanda Sproule, Christopher N. Boddy, David P. Overy, and Myron L. Smith Fungal Genet. Biol. 2021 |
Apicidin biosynthesis is linked to accessory chromosomes in Fusarium poae isolates.
Thomas E. Witte, Linda J. Harris, Hai D. T. Nguyen, Anne Hermans, Anne Johnston, Amanda Sproule, Jeremy R Dettman, Christopher N Boddy, David P. Overy BMC Genomics, 2021 |
Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria. Puneet Labana, Mark H. Dornan, Matthew Lafrenière, Tomasz L. Czarny, Eric D. Brown, John P. Pezacki, Christopher N. Boddy Cell Chem. Biol. 2021 |
Accessory Chromosome-Acquired Secondary Metabolism in Plant Pathogenic Fungi: The Evolution of Biotrophs Into Host-Specific Pathogens
Thomas E. Witte, Nicolas Villeneuve, Christopher N. Boddy, David P. Overy Front. Microbiol. 2021 |
2020
Thioesterase from Cereulide Biosynthesis Is Responsible for Oligomerization and Macrocyclization of a Linear Tetradepsipeptide.
Graham W. Heberlig, Christopher N. Boddy J. Nat. Prod. 2020 |
2019
Whole Genome Sequencing and Metabolomic Study of Cave Streptomyces Isolates ICC1 and ICC4.
Jessica Thandara Gosse, Soumya Ghosh, Amanda Sproule, David Overy, Naowarat Cheeptham, Christopher N. Boddy Front. Microbio. 2019 |
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.
Nicolas Huguenin-Dezot, Diego A. Alonzo, Graham W. Heberlig, Mohan Mahesh, Duy P. Nguyen, Mark H. Dornan, Christopher N. Boddy, T. Martin Schmeing, Jason W. Chin Nature 2019 |
2018
Draft Genome Sequence of the Type Strain Streptomyces armeniacus ATCC 15676.
Puneet Labana, Jessica T. Gosse, Christopher N. Boddy Microbiol. Resour. Announc. 2018 |
Inhibition of Bacterial Gene Transcription with an RpoN-Based Stapled Peptide.
Sterling R Payne, Daniel I. Pau, Amanda L. Whiting, Ye Joon Kim, Blaze M. Pharoah, Christina Moi, Christopher N. Boddy, Federico Bernal Cell Chem. Biol. 2018 |
Chemoenzymatic macrocycle synthesis using resorcylic acid lactone thioesterase domains.
Graham W Heberlig, Jesse T. C. Brown, Ryan D Simard, Monica Wirz, Wei Zhang, Meng Wang, Leah I. Susser, Mark E. Horsman, Christopher N. Boddy Org. Biomol. Chem. 2018 |
2017
Inducible T7 RNA Polymerase-mediated Multigene Expression System, pMGX.
Mohamed I. Hassan, Fern R. McSorley, Kinya Hotta, Christopher N. Boddy J. Vis. Exp. 2017 |
Sampling Terrestrial Environments for Bacterial Polyketides.
Patrick Hill, Graham W. Heberlig, Christopher N Boddy Molecules 2017 |
2016
Natural products: Mapping an amazing thicket.
Mark E. Horsman, Christopher N. Boddy Nat. Chem. Biol. 2016 |
Portable, On-Demand Biomolecular Manufacturing.
Keith Pardee, Shimyn Slomovic, Peter Q. Nguyen, Jeong Wook Lee, Nina Donghia, Devin Burrill, Tom Ferrante, Fern R. McSorley, Yoshikazu Furuta, Andyna Vernet, Michael Lewandowski, Christopher N. Boddy, Neel S. Joshi, James J. Collins Cell 2016 |
Total Biosynthesis of Legionaminic Acid, a Bacterial Sialic Acid Analogue.
Mohamed I. Hassan, Benjamin R Lundgren, Michael Chaumun, Dennis M. Whitfield, Brady Clark, Ian C. Schoenhofen, Christopher N. Boddy Angew. Chem. Int. Ed. Engl. 2016 |
First-in-class small molecule potentiators of cancer virotherapy.
Mark H Dornan, Ramya Krishnan, Andrew M. Macklin, Mohammed Selman, Nader El Sayes, Hwan Hee Son, Colin Davis, Andrew Chen, Kerkeslin Keillor, Penny J Le, Christina Moi, Paula Ou, Christophe Pardin, Carlos R. Canez, Fabrice Le Boeuf, John C Bell, Jeffrey C. Smith, Jean-Simon Diallo, Christopher N. Boddy Nat. Sci. Rep. 2016 |
Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis
Panos Argyropoulos, Fabien Bergeret, Christophe Pardin, Janice M Reimer, Atahualpa Pinto, Christopher N Boddy, T Martin Schmeing Biochim. Biophys. Acta. 2016 |
Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?
Mark E Horsman 1, Taylor P A Hari 1, Christopher N Boddy 1 Nat Prod Rep. 2016 |
Diastereoseletive Transannular Oxa-Conjugate Addition Generates the 2,6-cis-Disubstituted Tetrahydropyran of Neopeltolide.
Taylor P A Hari 1, Burkardt I Wilke 2, James A Davey 1, Christopher N Boddy 1 J. Org. Chem. 2016 |
The Use of ClusterMine360 for the Analysis of Polyketide and Nonribosomal Peptide Biosynthetic Pathways.
Nicolas Tremblay, Patrick Hill, Kyle R. Conway, Christopher N. Boddy Methods Mol. Biol. 2016 |
2015
Draft Genome Sequence of Streptomyces sp. Strain PBH53, Isolated from an Urban Environment
Jessica T Gosse, Patrick Hill, Scot E. Dowd, Christopher N. Boddy Genome Announc. 2015 |
Thermoplasmonic ssDNA Dynamic Release from Gold Nanoparticles Examined with Advanced Fluorescence Microscopy
Sabrina Simoncelli, Hasitha de Alwis Weerasekera, Chiara Fasciani, Christopher N. Boddy, Pedro F Aramendia, Emilio I Alarcon, Juan C Scaiano J. Phys. Chem. Lett. 2015 |
Modulation of antifreeze activity and the effect upon post-thaw HepG2 cell viability after cryopreservation
Chantelle J. Capicciotti, Jessica S. Poisson, Christopher N. Boddy, Robert N. Ben Cryobiology 2015 |
