< People

Boddy Group Members




The Boddy Lab is a highly interdisciplinary environment at the Chemistry/Biology interface. As such the researchers in the lab come from very diverse scientific backgrounds, including organic synthesis, biological chemistry, biochemistry, microbiology, microbial ecology, soil science, computational chemistry, chemical engineering, and bioinformatics. This diversity of skill sets makes for a dynamic, exciting research environment.

Principal Investigator



Big Bossman

 

Christopher N. Boddy

Ph.D. (The Scripps Research Institute)
B.Sc. (University of Alberta)


Department of Chemistry and Biomolecular Sciences
Department of Biology
Centre for Catalysis Research and Innovation
Centre for Chemical and Synthetic Biology






Current Group Members



Summer '17 featuring The Boddy Group

Back Row: Nathan Thioux (Visiting Student, France), Puneet Labana, Graham Heberlig, Jesse Brown, Kristy Scarfone
Front: Patrick Hill, Mohamed Hassan, Prof. Chris Boddy, Maggie Watson, Jessica Gosse


Graduate Students



Taylor Hari, M.Sc.

Taylor P. A. Hari

Ph.D. Chemistry Candidate
Visiting NSERC Researcher (Univ of Notre Dame)
M.Sc. Chemistry (uOttawa)
B.Sc. (hon.) Biopharmaceutical Sciences (uOttawa)

The central theme of Taylor's graduate work is the synthesis of complex macrocyclic natural products. This research focuses on the feasibility of a transannular oxa-conjugate route to 2,6-cis-pyrans, like the one found in the highly cytotoxic marine natural product neopeltolide. Using a model substrate, reaction conditions have been identified that led to thermodynamic control for this reversible addition, in high diastereoselectivity. The observed cis-to-trans product ratio is in good agreement with computationally predicted equilibrium ratios. Evaluation of this transannular oxa-conjugate addition will be examined through his total synthesis of neopeltolide, with an emphasis on whether remote stereocontrol is sufficient to control both THP stereogenic centers.

Additionally, Taylor conducts chemoenzymatic studies to characterize the biosynthetic details of macrocyclization using the 6-deoxyerythronolide B synthase thioesterase domain (DEBS TE). DEBS is considered the canonical macrocyclizing enzyme in polyketide natural products, and the synthesis of enantioenriched non-native linear substrates provides an understanding of the effect of absolute stereochemical configuration on the enzyme’s selectivity for macrocyclization.

Thesis Topic:
Total synthesis and chemoenzymatic synthesis of the marine anticancer polyketide neopeltolide A




P. Hill, M.Sc.

Patrick Hill

Ph.D. Biology Candidate
M.Sc. (University of Reading)
B.Sc. (Guelph University)

Thesis Topic:
Characterizing the community structure of antibiotic producing bacteria in diverse environments

 

 

 

  

 

 

 

Graham Heberlig, B.Sc.

Graham Heberlig

Ph.D. Chemistry Candidate
B.Sc. Biochemistry (SUNY ESF)

Thesis Topic:
Harnessing polyketide biosynthetic pathways to produce complex molecules

 

 

Jessica Gosse, M.Sc.

Jéssica Gosse

Ph.D. Chemistry Candidate
M.Sc. Genetics and Molecular Biology (UNICAMP, Brazil)
B.Sc. Biology (UNICAMP, Brazil)

Jessica has a background in parasitology and microbiology and her work is focused in bioprospecting environmental DNA to build genomic libraries and identify novel bacterial products, such as polyketides and non ribosomal peptides, molecules that have a wide range of uses as antibiotics, anticancer agents and immune system suppressors.

Thesis Topic:
Bioprospecting the metagenome for new polyketide natural products

  

 



Mohamed Hassan, B.Sc.

Mohamed Hassan

Ph.D. Chemistry Student
B.Sc. (hon.) Biopharmaceutical Sciences (uOttawa)

Thesis Topic:
Production of high value monosaccharides from metabolically and genetically engineered Escherichia coli

 

 

 

 

 

 

 

 


Puneet Labana, B.Sc.

Puneet Labana

Ph.D. Chemistry Student
B.Sc. (hon.) Biopharmaceutical Sciences (uOttawa)

Thesis Topic:
Mechanism of armenaspirole antibiotic activity

 

 

 

 

  

 

 

Jesse Brown, B.Sc.

Jesse Brown

M.Sc. Chemistry Candidate
B.Sc. (hon.) Chemistry (Carleton)

 

 

 

 


Visiting Scientists



Maggie Watson

Maggie Watson
Alain Lab, CHEO


Undergraduate Students



Kristy Scarfone (Honours)
David Schlachter (Honours)
Kelvin Xu (Visiting Student, China)


Group Alumni

Post-Doctoral & Visiting Scientists



Eve Granatosky (University of Notre Dame)
Fern R. McSorley (PDF, McMaster University)
Jack Melton (President ProcesScience Inc)
Christophe Pardin (Professor, Cégep de l'Outaouais)
Zaara Sarwar (PDF, Syracuse University)
Céline Valignat (L'université d'Orléans)
Jeanette Young (PDF, Indiana University School of Medicine)

Graduate Students



Panos Argyropoulos (Health, Safety, & Risk Assistant, uOttawa)
Kyle Conway
(Aircraft Systems Simulation Engineer, TRU Simulation and Training)
Mark Dornan (PDF, Université de Montréal)
David Dixson (Scientist III, Boehringer Ingelheim)
Mark Horsman (PDF, Notre Dame)
Steve Houghton (Senior Scientist, Syracuse Research Corp)
Ben Lundgren (PDF, SUNY ESF)
Atahualpa Pinto (PDF, SUNY ESF)
Daniel Pau (University of Toronto, School of Medicine)
Krishna Sharma (Sr. Engineer/Scientist R&D, UOP LLC)
Cole Stevens (Assistant Professor, University of Mississippi)
Luis Roberto Villegas-Peñaranda (Universidad Nacional, Costa Rica)
Meng Wang (Professor, Tianjin Institute of Industrial Biotechnology)
Burk Wilke (PDF, Syracuse University)
Monica Wirz (University of Waterloo, School of Pharmacy)

Undergraduate Students



Christine Achampong
Nadine Ahmed
Noreen Ahmed
Bachar Almazloum
Nathan Baratte
Meaghan Boileau (McGill University)
Chauncy Brown
Alyssa Caissie
Benjamin Chung (University of Toronto)
Melanie Cyr
Malay Doshi (Paraza Pharma)
Touria El-Aamri (Université Pierre et Marie Curie, France)
Amedeo Falsetto (University of Toronto, School of Medicine)
Laura Furst (Boston University)
Jeremy Gardner (University of Ottawa, School of Medicine)
Hakim Gol
Alyssa Goto
Joeseph Grim (University of Wisconsin)
Kofi Gyan (Tufts University)
Mike Henry (US Army)
Michael Innes
Anitha Kammili
Joshua Kandiah
Evan Koester
David Konrad (Germany)
Kevin Lafaye (France)
Clémence Larfague (Ecole Normale Supérieure, France)
Daniel Langevin
Penny Le 
Sanjay Manhas (University of Toronto, Taylor Group)
Rachel Marchand
Kyle McClymont (The Scripps Research Institute, Baran Group)
Erwin Mendoza
Christina Moi (Queen's University, School of Medicine)
R.J. Mortali
Sue Moon
Haytham Msallak
Tyler Murray (University of Toronto, School of Medicine)
Peter Opare
Nelson Pearce (Pharmacist, Brockville Mental Health Centre)
Curtis Quan
Stefan Raffalt
Bo Reichenbach 
Mariya Ryabushkina
Daniel Serrano
Ryan Simard (Université de Montréal, Guindon Group)
Sabrina Slade (Queen's University, School of Medicine)
Leah Susser
Daniel Tesolin (Lakehead University, Phenix Group)
Angela Thompson
Chelsea Towaij (University of Toronto, School of Medicine)
Birgit Unterweger
Anthony Valenti
Evelyn Walenta
Laura Walker
Lisa Zhang
Nick Zinck 

Past Group Photos



December 2012
Boddy Collage
2010
2009
2007